報(bào)告人：嚴(yán)軍　博士生導(dǎo)師，研究員

報(bào)告人介紹：

1998-2003   美國(guó)紐約大學(xué)物理系   博士
2003-2006   美國(guó)阿拉斯加大學(xué)   博士后

2006-2015  中科院－德國(guó)馬普學(xué)會(huì)計(jì)算生物學(xué)研究所 研究員
2015-至今     中科院上海生科院神經(jīng)科學(xué)研究所   研究員

主要研究工作內(nèi)容：

1.全腦介觀腦圖譜、神經(jīng)元全腦投射圖譜的重建與分析；

 2.采用計(jì)算生物學(xué)、生物信息學(xué)、系統(tǒng)生物學(xué)的方法，針對(duì)小鼠、斑馬魚(yú)等模式生物開(kāi)展生物節(jié)律神經(jīng)網(wǎng)絡(luò)、基因調(diào)控網(wǎng)絡(luò)的研究。

代表性論文(*通訊作者)：  

1.Fan, Z., Zhao,  M., Joshi, P., Li, P., Zhang, Y., Guo, W., Xu, Y., Wang, H., Zhao, Z., Yan, J.  (2017) A class of circadian long non-coding RNAs mark enhancers modulating  long-range circadian gene regulation. Nucleic. Acids. Res. doi:  10.1093/nar/gkx156

2.Xu, Y., Guo, W.,  Li, P., Zhang, Y., Zhao, M., Fan, Z., Zhao, Z., Yan, J. (2016) Long-range  chromosome interactions mediated by cohesin shape circadian gene expression.  PLOS Genetics 10.1371

3.Li, Y., Li, G.,  G?rling, B., Luy, B., Du, J., and Yan, J. (2015) Integrative Analysis of  Circadian Transcriptome and Metabolic Network Reveals the Role of de novo Purine  Synthesis in Circadian Control of Cell Cycle. PLoS computational biology. 11(2):  e1004086.

4.Liu, J., Wang,  X., Li, J., Wang, H., Wei, G., Yan, J. (2014) Reconstruction of the Gene  Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role  in Early Development of the Mouse Brain. PLoS computational biology.  10(10):e1003884.

5.Liu, Y., Hu, W.,  Murakawa, Y., Yin, J., Wang, G., Landthaler, M., and Yan, J. (2013).  Cold-induced RNA-binding proteins regulate circadian gene expression by  controlling alternative polyadenylation. Scientific reports 3, 2054.

6.Li, Y., Li, G.,  Wang, H., Du, J., and Yan, J. (2013). Analysis of a gene regulatory cascade  mediating circadian rhythm in zebrafish.PLoS computational biology 9,  e1002940.

7.Wang, H., Liu,  Y., Briesemann, M., and Yan, J. (2010).Computational Analysis of Gene  Regulations in Animal Sleep Deprivation.Physiol Genomics 42,  427-436.

8.Shao, C., Liu,  Y., Ruan, H., Li, Y., Wang, H., Kohl, F., Goropashnaya, A.V., Fedorov, V.B.,  Zeng, R., Barnes, B.M., Yan, J. (2010).Shotgun proteomics analysis of  hibernating arctic ground squirrels.Mol Cell Proteomics 9, 313-326.

9.Yan, J., Wang,  H., Liu, Y., and Shao, C. (2008). Analysis of gene regulatory networks in the  mammalian circadian rhythm.PLoS computational biology 4, e1000193..

報(bào)告二題目：感知與抉擇的神經(jīng)環(huán)路運(yùn)算

報(bào)告人：徐寧龍　博士生導(dǎo)師，研究員

報(bào)告人介紹：

1999-2006   中國(guó)科學(xué)院神經(jīng)科學(xué)研究所   博士
2006-2008   美國(guó)冷泉港實(shí)驗(yàn)室   博士后

2008-2013   美國(guó) HHMI Janelia Research Campus 博士后

2013-至今     中科院上海生科院神經(jīng)科學(xué)研究所   研究員

主要研究方向：

  1.  我們?cè)趫?zhí)行聽(tīng)覺(jué)感知抉擇任務(wù)的小鼠中，使用雙光子顯微鏡觀察大腦皮及皮層下神經(jīng)元的電信號(hào)，以揭示聽(tīng)覺(jué)感知與行為抉擇的神經(jīng)編碼原理；

2.  我們使用光遺傳學(xué)和化學(xué)遺傳學(xué)等神經(jīng)環(huán)路干預(yù)技術(shù)，揭示各個(gè)腦區(qū)及它們之間形成的環(huán)路在感知與抉擇中的作用機(jī)制；

3.  我們與人工智能研究人員合作，探索如何將動(dòng)物面對(duì)復(fù)雜感覺(jué)信息進(jìn)行行為抉擇的神經(jīng)計(jì)算原理應(yīng)用于機(jī)器智能技術(shù)開(kāi)發(fā)。

代表成果

1. Wang Z, Xu NL, Wu CP, Duan S*, and  Poo MM*, Bidirectional changes in spatial dendritic integration accompanying  long-term synaptic modifications. Neuron, 37: 463-72  (2003).

2. Xu NL, Ye CQ, Zhang XH*, and Poo  MM*, Coincidence detection of synaptic inputs is facilitated at the distal  dendrites after long-term potentiation induction. J. Neurosci., 26: 3002-3009  (2006).

3. Xu NL, Harnett MT,  O’Connor DH, Huber D, Williams SR, Svoboda K., Magee JC*,  Nonlinear dendritic integration of sensory and motor input during an active  sensing task. Nature, 492: 247-251 (2012).

4. Petreanu L, Gutnisky DA, Huber D,  Xu NL, O’Connor DH, Tian L, Looger L, and Svoboda K*,  Activity in motor-sensory projections reveals distributed coding in  somatosensation. Nature, 489: 299–303  (2012).

5. Harnett MT, Xu NL, Magee JC*,  Williams SR*, Potassium Channels Control the Interaction between Active  Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons.  Neuron, 79: 516-529 (2013).

6. Chen JL*, Andermann ML, Keck T, Xu  NL, and Ziv Y, Imaging Neuronal Populations in Behaving Rodents: Paradigms for  Studying Neural Circuits Underlying Behavior in the Mammalian Cortex. J.  Neurosci., 33(45): 17631-17640 (2013).

7. Guo ZV, Hires SA, Li N, O'Connor  DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S,  Xu NL, Cox J, Svoboda K*, Procedures for Behavioral Experiments in Head-Fixed  Mice. PLoS ONE , 9, e88678 (2014).

時(shí)間：2018年4月25日下午6：00

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